2010-2014

2014

  • Díaz, J., Díaz, N., Leyton, L., Torres, V. and Quest, A.F.G. “Molecular insights to a novel Caveolin-1 Rab5-Rac1 signaling pathway important for metastatic cancer cell migration and invasion”. Cancer Cell & Microenviroment 2014; 1: e332
  • Ponce, D., Salech, F., SanMartin, C., Silva, M., Xiong, Ch., Roe, C., Henriquez, M., Quest, A.F.G. and Behrens, M.I. “Increased Susceptibility to Oxidative Death of Lymphocytes from Alzheimer Patients Correlates with Dementia Severity”. Curr Alzheimer Res. 2014;11(9):892-8. PubMed Link
  • Díaz, J., Mendoza, P., Silva, P., Quest, A.F.G.*, and Torres, V.A.* “A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion”. Commun Integr Biol. 2014 Oct; 7(5): e972850. *Corresponding authors (equal contribution). PubMed Link
  • Fernández, JG., Rodríguez, D., Valenzuela, M., Calderon, C., Urzúa, U., Munroe, D., Rosas, C., Lemus, C., Díaz, C., Wright, M., Leyton, L., Tapia, J., and Quest, A.F.G. “Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent transcription”. Mol Cancer 13: 209 (2014). PubMed Link
  • Díaz, J., Mendoza, P.,Ortiz, R., Díaz, N., Leyton, L., Stupack, D., Quest, A.F.G., Torres, V. “Rab5 is required in metastatic cancer cells for Caveolin-1-enhanced Rac1 activation, migration and invasion”. J Cell Sci. 127: 2401-2406 (2014). PubMed Link
  • Lobos-Gonzalez, L., Aguilar-Guzmán, L., Fernandez, J., Muñoz, N., Hossain, M., Bieneck, S., Silva, V., Burzio, V., Sviderskaya, E., Bennett, D., Leyton, L. and Quest, A.F.G. “Caveolin-1 is a risk factor for postsurgery metastasis in preclinical melanoma models”. Melanoma Res. 24:108-119 (2014). PubMed Link
  • Bravo-Sagua, R., Torrealba, N., Paredes, F., Morales P., Pennanen, C., López-Crisosto, C., Troncoso, R., Criollo, A., Chiong, M., Hill, J., Simmen, T., Quest, A.F.G., Lavandero, S. “Organelle communication: Signaling crossroads of homeostasis and disease”. Int J Biochem Cell Biol. 50:55-59 (2014). PubMed Link
  • Aguilar-Guzman, L., Lobos-Gonzalez, L., Rosas, C., Vallejos, G., , Falcon, C., Sosoniuk, E., Coddou, F., Leyton, L., Lemus, D., Quest, A.F.G.*, and Ferreira, A.* “Human Survivin and Trypanosoma cruzi Calreticulin Act in Synergy against a Murine Melanoma In Vivo”. PLoS One. 2014 Apr 22;9(4):e95457. *Corresponding authors (equal contribution). PubMed Link
  • Núñez-Wehinger, S., Ortiz, R., Díaz, N., Díaz, J., Lobos-González, L. and Quest, A.F.G. “Caveolin-1 in Cell Migration and Metastasis”. Curr Mol Med. 2014 Feb;14(2):255-274 (2014). PubMed Link
  • Díaz, J., Díaz, N., Leyton, L., Torres, V.A.*, and Quest, A.F.G.* “Molecular mechanisms implicated in Caveolin 1 dependent Rab5 activation, migration and invasion of metastatic cancer cells”. Cancer Cell & Microenvironment 2014; 1: e332. *Corresponding authors (equal contribution).
  • Ávalos, Y., Canales, J., Bravo-Sagua, R., Criollo, A., Lavandero, S. and Quest, A.F.G. “Tumor suppression and promotion by autophagy”. Biomed Res Int. 2014;2014:603980. PubMed Link
  • Leyton L, Torres VA, Quest A.F.G. “Editorial: Signaling in Cell Migration and Disease”. Curr. Mol. Med. 14: 197-198 (2014). PubMed Link
  • Cárdenas, A., Kong, M., Alvarez, A., Maldonado, H., Leyton, L. “Signaling pathways involved in neuron-astrocyte adhesion and migration”. Current Molecular Medicine 14(2):275-290 (2014). PubMed Link

Book Chapter

  • Leyton, L., and J. Hagood. “Thy-1 modulates neurological cell-cell and cell-matrix interactions through multiple molecular interactions” in “Cell Adhesion Molecules: Implications in Neurological Diseases”. Advances in Neurobiology. Editorial: Springer Science, New York, USA, Chapter 1, Páginas 3-20, 2014. PubMed Link

2013

  • Mendoza, P., Ortiz, R., Díaz, J., Quest,AFG., Leyton, L., Stupack, D., Torres, V. “Rab5 activation promotes focal adhesion disassembly, migration and invasiveness in tumor cells”. Journal of cell science. 126(12): 3835-3847 (2013). PubMed Link
  • Ormazabal, P., Romero, C., Quest, AFG., Vega, M. “Testosterone Modulates the Expression of Molecules Linked to Insulin Action and Glucose Uptake in Endometrial Cells”. Hormone and Metabolic Research. 45(09): 640-645 (2013). PubMed Link
  • Parra V., Moraga F., Kuzmicic J., López-Crisosto C., Troncoso R., Torrealba N., Criollo A., Díaz J., Rothermel B., Quest AFG., Lavandero S. “Calcium and mitochondrial metabolism in ceramide-induced cardiomyocyte death”. Biochim Biophys Acta. 1832:1334-1344 (2013). PubMed Link
  • Valenzuela M., Bravo D., Canales J., Sanhueza C., Díaz N., Almarza O., Toledo H., Quest AFG. “Helicobacter pylori-induced loss of survivin and gastric cell viability is attributable to secreted bacterial gamma-glutamyl transpeptidase activity”. J Infect Dis. 208: 1131-1141 (2013). PubMed Link
  • Lobos, L., Aguilar, L., Diaz, J., Diaz, N., Urra, H., Torres, V., Silva, V., Fitzpatrick, C., Lladser, A., Hoek, K., Leyton, L., Quest, AFG. “E‐cadherin determines Caveolin‐1 tumor suppression or metastasis enhancing function in melanoma cells”. Pigment cell & melanoma research. 26(4): 555-570. PubMed Link
  • Kong, M., Muñoz, N., Valdivia, A., Alvarez, A., Herrera-Molina, R., Cárdenas, A., Schneider, P., Burridge, K., Quest, A.F.G., and Leyton, L.“Thy-1-mediated Cell -Cell Contact Enhances Cell-Matrix Adhesion and Migration through the Engagement of αVβ3 Integrin and Syndecan-4”. BBA-Mol Cell Res. 1833:1409-1420 (2013). PubMed Link
  • Castro I., Sepúlveda D., Cortés J., Quest AFG., Barrera MJ., Bahamondes V., Aguilera S., Urzúa U., Alliende C., Molina C., González S., Hermoso MA., Leyton C., González MJ. “Oral dryness in Sjögren’s syndrome patients. Not just a question of water”. Autoimmun Rev. 12:567-574 (2013). PubMed Link
  • Barrera MJ., Bahamondes V., Sepúlveda D., Quest AFG., Castro I., Cortés J., Aguilera S., Urzúa U., Molina C., Pérez P., Ewert P., Alliende C., Hermoso MA., González S., Leyton C., González MJ. “Sjögren’s syndrome and the epithelial target: acomprehensive review”. J Autoimmun. 42:7-18 (2013). PubMed Link
  • Quest, A.F.G., Lobos-González, L., Nuñez, S., Sanhueza, C., Fernández, J.-G., Aguirre, A., Rodríguez, D., Leyton, L., Torres, V. “The caveolin-1 connection to cell death and survival”. Mol. Med. 13(2):266-81 (2013). PubMed Link
  • Smaili, SS., Quest,AF., Hetz, C., Lavandero, S. “Editorial: signaling in cell death, survival, proliferation and degeneration”. Current molecular medicine. 13(2): 239-240 (2013). PubMed Link
  • Aguirre, A., Shoji,KF., Sáez, JC., Henríquez, M., Quest, AFG. “FasL‐triggered death of Jurkat cells requires caspase 8‐induced, ATP‐dependent cross‐talk between fas and the purinergic receptor P2X(7)”. Journal of cellular physiology. 228(2): 485-493 (2013). PubMed Link
  • Ibarra C., Vicencio JM., Estrada M., Lin Y., Rocco P., Rebellato P., Muñoz JP., Garcia-Prieto J., Quest AFG., Chiong M., Davidson SM., Bulatovic I., Grinnemo KH., Larsson O., Szabadkai G., Uhlén P., Jaimovich E., Lavandero S. “Local control of nuclear calcium signaling in cardiac myocytes by perinuclear microdomains of sarcolemmal insulin-like growth factor 1 receptors”. Circ Res 112(2):236-245 (2013). PubMed Link
  • P Ormazabal, C Romero, F Gabler, AFG Quest, M Vega. “Decreased phosphorylation of Y¹⁴caveolin-1 in endometrial tissue of polycystic ovary syndrome patients may be related with an insulin resistant state in this tissue”. Hormone and metabolic research. 45(04):291-296 (2013). PubMed Link
  • Herrera-Molina, R., Valdivia, A., Kong, M., Alvarez, A., Cárdenas, A., Quest, AFG., Leyton, L. “Thy-1-interacting molecules and cellular signaling in both Cis and trans”. International Reviews of Cell and Molecular Biology. 305: 163-216 (2013). PubMed Link
  • Bravo R., Parra V., Gatica D., Rodríguez AE., Torrealba N., Paredes F., Wang ZV., Zorzano A., Hill JA., Jaimovich E., Quest AFG., Lavandero S. “Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration”. Int Rev Cell Moll Biol 301:215-290 (2013). PubMed Link
  • Fan Y., Abrahamsen G., Mills R., Calderón C., Tee J.Y., Leyton L., Murrell W., Cooper-White J., McGrath J.J., Mackay-Sim A. “Focal adhesion dynamics are altered in schizophrenia”. Biol Psychiatry. 74:418-426 (2013). PubMed Link

2012

  • Barrera MJ, Sánchez M, Aguilera S, Alliende C, Bahamondes V, Molina C, Quest AF, Urzúa U, Castro I, González S, Sung HH, Albornoz A, Hermoso M, Leyton C, González MJ. “Aberrant localization of fusion receptors involved in regulated exocytosis is salivary glands of Sjoegrens Syndrome patients is linked to ectopic mucin secretion”. Journal of Autoimmunity 39:83-92 (2012). PubMed Link
  • Urra, H., Torres, V.A., Ortiz, R., Lobos-Gonzalez, L., Díaz, M.I., Díaz, N., Härtel, S., Leyton, L.*, Quest, A.F.G.* “Caveolin-1-enhanced motility and focal adhesion turnover require tyrosine-14 but not accumulation to the rear in metastatic cancer cells”. PLoS One. 7(4):e33085.*Corresponding authors (equal contribution). PubMed Link
  • González, S., Aguilera, S., Urzúa, U., Quest,AFG., Molina, C., Alliende, C., Hermoso, M., González, M. Corrigendum to “Mechanotransduction and epigenetic control in autoimmune diseases”. J. Autoimmun. Rev. 11 (5) 375 (2012).
  • Herrera-Molina, R., Frischknecht, R., Maldonado, H., Seidenbecher, C.I., Gundelfinger, E.D., Hetz, C., Aylwin, M.L., Schneider, P., Quest, A.F.G., and Leyton, L. “Astrocytic αVβ3 Integrin Inhibits Neurite Outgrowth and Promotes Retraction of Neuronal Processes by Clustering Thy-1”. PLoS One. 7(3):e34295 (2012). PubMed Link
  • Castro, I., Aguilera, S., Brockhausen, I., Alliende, C., Quest, A.F.G.,Molina, C., Urzúa, U., Mandel, U., Bahamondes, V., Barrera, M.-J., Sánchez, M., González, S., Hermoso, M., Leyton, C., and González, M.-J. “Decreased salivary sulphotransferase activity correlated with inflammation and autoimmunity parameters in Sjoegrens Syndrome patients”. Rheumatology (Oxford). Mar;51(3):482-90 (2012). PubMed Link
  • Behrens, M.I., Silva, M., Salech, F., Ponce, D.P., Merino, D., Sinning, M., Xiong, C., Roe, C.M., Quest, A.F.G. “Inverse Susceptibility to Oxidative Death of Lymphocytes Obtained From Alzheimer’s Patients and Skin Cancer Survivors: Increased Apoptosis in Alzheimer’s and Reduced Necrosis in Cancer”. J Gerontol A Biol Sci Med Sci. glr258 (2012). PubMed Link
  • Bravo, R., Gutierrez, T., Paredes, F., Gatica, D., Rodriguez, A.E., Pedroso, Z., Chiong, M., Parra, V., Quest, A.F.G., Rothermel B.A., Lavandero, S. “Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics”. Int J Biochem Cell Biol:44, 16-20 (2012). PubMed Link
  • Perez-Donoso, J.M., Monras J.P., Bravo, D., Aguirre, A., Quest, A.F.G., Osorio-Roman, I.O., Aroca, R.F., Chasteen, T.G.,Vasquez, C.C. “Biomimetic, mild chemical synthesis of CdTe-GSH quantum dots with improved biocompatibility”. PLoS One. 7(1):e30741 (2012). PubMed Link
  • Copaja, M., Venegas, D., Aránguiz, P., Canales, J., Vivar, R., Avalos, Y., García, L., Chiong, M., Olmedo, I., Catalán, M., Leyton, L., Lavandero, S. and Díaz-Araya, G.“Simvastatin disrupts cytoskeleton and decreases cardiac fibroblast adhesion, migration and viability”. 294:42-49 (2012). PubMed Link
  • Diaz J, Aranda E, Henriquez S, Quezada M, Espinoza E, Bravo ML, Oliva B, Lange S, Villalon M, Jones M, Brosens JJ, Kato S, Cuello MA, Knutson TP, Lange CA, Leyton L., Owen GI. “Progesterone promotes focal adhesion formation and migration in breast cancer cells through induction of protease-activated receptor-1″J Endocrinol. 214(2):165-175 (2012). PubMed Link
  • A.F.G. Quest, V. Torres, D. Rodriguez, J. Gutierrez-Pajares, J.C. Tapia. Caveolin-1 in colon cancer: the flexible connection to Wnt signaling. Caveolins in Cancer Pathogenesis, Prevention and Therapy. 17-41 (2012)

2011

  • Armisén, R., Marcelain, K., Simon, F., Tapia, J.C., Toro, J., Quest, A.F.G., and Stutzin, A. “TRPM4 enhances cell proliferation through up-regulation of the β-catenin signaling pathway”. Cell Physiol 226: 103-109 (2011). PubMed Link
  • Bahamondes V., Albornoz A., Aguilera S., Alliende C., Molina C., Castro I., Urzúa U., Quest, A.F.G., Barrera M.J., González S., Sánchez M., Härtel S., Hermoso M., Leyton C., González M.J. “Changes in Rab3D expression and distribution in the acini of Sjögren’s syndrome patients are associated with loss of cell polarity and secretory dysfunction”. Arthritis Rheum. 2011 Oct; 63(10): 3126-35. doi: 10.1002/art.30500. PubMed Link
  • Behrens, M.I., Silva, M., Schmied, A., Salech, F., Manzur, H., Rebolledo, R., Bull, R., Torres, V., Henriquez, M., Quest, A.F.G. “Age-dependent increases in apoptosis/necrosis ratios in human lymphocytes exposed to oxidative stress”. J Gerontol A Biol Sci Med Sci 66: 732-740 (2011). PubMed Link
  • Bravo, D., Blondel, C.J., Hoare, A., Leyton, L.,Valvano, M.A., and Contreras, I. “Type IV(B) pili are required for invasion but not for adhesion of Salmonella enterica serovar Typhi into BHK epithelial cells in a cystic fibrosis transmembrane conductance regulator-independent manner”. Microb. Pathog. 51:373-377 (2011). PubMed Link
  • Copaja, M., Venegas, D., Aránguiz, P., Canales, J., Vivar, R., Catalán, M., Olmedo, I., Rodríguez, A.E., Chiong, M., Leyton, L., Lavandero, S. and Díaz-Araya, G. “Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts”. Toxicol. Appl. Pharmacol. 255:57-64(2011). PubMed Link
  • Ehrenfeld, P., Conejeros, I., Pavicic, M.F., Matus, C.E., Gonzalez, C.B., Quest, A.F.G., Bhoola, K.D., Poblete, M.T., Burgos, R.A., Figueroa, C.D. “Activation of kinin B1 receptor increases the release of metalloproteases-2 and -9 from both estrogen-sensitive and -insensitive breast cancer cells”. Cancer Letters 301: 106-118 (2011). PubMed Link
  • Gonzalez, S., Aguilera, S., Alliende, C., Urzua, U., Quest, A.F.G., Herrera, L., Molina, C., Hermoso, M., Ewert, P., Brito, M., Romo, R., Leyton, C., Perez, P., González M.J. “Alterations in Type-I hemidesmosome components suggestive of epigenetic control in the salivary glands of patients with Sjoegren’s syndrome”. Arthritis Rheum. 63:1106-1115 (2011). PubMed Link
  • Gonzalez, S., Aguilera, S., Urzua, U., Quest, A.F.G., Molina, C., Alliende, C., Hermoso, M., González M.J. “Mechanotransduction and epigenetic control in autoimmune diseases”. Autoimmune Rev, 10: 175-179(2011). PubMed Link
  • Henríquez, M, Herrera-Molina, R., Valdivia, A., Alvarez, A., Kong, M., Muñoz, N., Eisner, V., Jaimovich, E., Schneider, P., Quest, A.F.G.*, Leyton, L.* “ATP release due to Thy-1-integrin binding induces P2X7-mediated calcium entry required for focal adhesion formation” Cell Sci.124: 1581-1588(2011). *Corresponding authors (equal contribution). PubMed Link
  • Henríquez, S., Calderon, C., Quezada, M., Oliva , B., Bravo, M.L., Aranda, E., Kato, S., Cuello, M.A., Gutiérrez, J., Quest , A.F.G., and Owen, G.I. “Progesterone utilizes distinct membrane pools of Tissue Factor to increase coagulation and invasion and these effects are inhibited by TFPI” Cell Physiol. 226: 3278-3285(2011). PubMed Link
  • Herrera-Marschitz M, Morales P, Leyton L, Bustamante D, Klawitter V, Espina Marchant P, Allende C, Lisboa F, Cunich G, Jara-Cavieres A, Neira T, Gutierrez-Hernandez M.A., Gonzalez-Lira V, Simola N, Schmitt A, Morelli M, Tasker A, Gebicke-Haerter P.J. “Perinatal asphyxia: current status and approaches towards neuroprotective strategies, with focus on sentinel proteins”. Neurotox Res. 19(4):603-627 (2011). PubMed Link
  • Lladser, A.,*Sanhueza, C., Kiessling, R., Quest, A.F.G.* “Is survivin the potential archilles’ heel of cancer?” (invited review) Advances in Cancer Research 111: 1-37(2011). *Corresponding authors (equal contribution). PubMed Link
  • Lladser, A., Mougiakakos, D., Tufvesson, H., ,Ligtenberg, M.A., Quest, A.F.G., Kiessling R., Ljungberg, K. “DAI (DLM-1/ZBP1) as a DNA genetic adjuvant for DNA vaccines that promotes effective antitumor CTL immunity”. Mol Ther. 19: 594-601 (2011). PubMed Link
  • Yefi, R.,, Ponce, D.P., Niechi, I., Silva, E., Cabello, P., Rodríguez, D.A., Marcelain, K., Armisen, R., Quest, A.F.G.*, Tapia, J.* “Protein kinase CK2a promotes cancer cell viability via upregulation of cyclooxygenase-2 expression and enhanced PGE2 production¨ Cell. Biochem 226: 1953-1959 (2011). *Corresponding authors (equal contribution). PubMed Link

2010

  • Ewert P., Aguilera S., Alliende C., Kwon Y.J., Albornoz A., Molina C., Urzúa U., Quest A.F., Olea N., Pérez P., Castro I., Barrera M.J., Romo R., Hermoso M., Leyton C., González M.J. “Disruption of tight junction function in salivary glands from Sjoegren’s syndrome patients is linked to pro-inflammatory cytokine exposure”Arthritis Rheum 62: 1280-1289 (2010). PubMed Link
  • Lladser, A., Ljungberg, K., Tufvesson, H., Tazzari, M., Roos, A.-K., Quest, A.F.G., Kiessling, R. “Intradermal DNA electroporation induces survivin-specific CTLs, suppresses angiogenesis and confers protection against mouse melanoma”. Cancer Immunol. Immunother. 59:81-92 (2010). PubMed Link
  • Valenzuela, M., Perez-Perez,, Corvalán, A.H., Carrasco, G., Urra, H., Bravo, D., Toledo, H., and Quest A.F.G. “Helicobacter Pylori-induced loss of the inhibitor of apoptosis protein survivin is linked to gastritis and death of human gastric cells” J. Inf. Disease 202: 1021-1030 (2010). PubMed Link