2015-2018

2018

  • Guerrero, S., Inostroza-Riquelme, M., Contreras-Orellana, P., Diaz-Garcia, V., Lara, P., Vivanco-Palma, A., Cárdenas, A., Miranda, V., Robert, P., Leyton, L., Kogan, M.J., Quest A.F.G., Oyarzun-Ampuero, F. “Curcumin-loaded nanoemulsion: a new safe and effective formulation to prevent tumor reincidence and metastasis”. Nanoscale. 2018 Dec 21;10(47):22612-22622. PubMed Link
  • Díaz-García, V.M., Guerrero, S., Díaz-Valdivia, N., Lobos-González, L., Kogan, M., Pérez-Donoso, J.M., Quest, A.F.G. “Biomimetic quantum dot-labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis by in vivo imaging”. Int J Nanomedicine. 2018 Oct 16;13:6391-6412. PubMed Link
  • Campos, A., Salomon, C., Bustos, R., Díaz, J., Martínez, S., Silva, V., Reyes, C., Díaz-Valdivia, N., Varas-Godoy, M., Lobos-González, L., Quest, A.F.G. “Caveolin-1-containing extracellular vesicles transport adhesion proteins and promote malignancy in breast cancer cell lines”. Nanomedicine (Lond). 2018 Oct;13(20):2597-2609. PubMed Link
  • Castillo Bennett, J., Silva, P., Martinez, S., Torres, V.A., Quest, A.F.G. “Hypoxia-Induced Caveolin-1 Expression Promotes Migration and Invasion of Tumor Cells”. Curr Mol Med. 2018;18(4):199-206. PubMed Link
  • Bravo-Sagua, R., Parra, V., Ortiz-Sandoval, C., Navarro-Marquez, M., Rodríguez, A.E., Diaz-Valdivia, N., Sanhueza, C., Lopez-Crisosto, C., Tahbaz, N., Rothermel, B.A., Hill, J.A., Cifuentes, M., Simmen, T., Quest, A.F.G., Lavandero, S. “Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER-mitochondria communication during the early phase of ER stress”. Cell Death Differ. 2018 Sep 12. PubMed Link
  • Peña-Oyarzun, D., Bravo-Sagua, R., Diaz-Vega, A., Aleman, L., Chiong, M., Garcia, L., Bambs, C., Troncoso, R., Cifuentes, M., Morselli, E., Ferreccio, C., Quest, A.F.G., Criollo, A., Lavandero, S. “Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?”. Free Radic Biol Med. 2018 Aug 20;124:61-78. PubMed Link
  • Bravo, D., Hoare, A., Soto, C., Valenzuela, M.A., Quest, A.F.G. “Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects”. World J Gastroenterol. 2018 Jul 28;24(28):3071-3089. PubMed Link
  • Lagos-Cabré, R., Brenet, M., Díaz, J., Pérez, R.D., Pérez, L.A., Herrera-Molina, R., Quest, A.F.G., Leyton, L. “Intracellular Ca2+ Increases and Connexin 43 Hemichannel Opening Are Necessary but Not Sufficient for Thy-1-Induced Astrocyte Migration.”. Int J Mol Sci. 2018 Jul 26;19(8). PubMed Link
  • Guerrero, S., Díaz-García, V.M., Contreras-Orellana, P., Lara, P., Palma, S., Guzman, F., Lobos-Gonzalez, L., Cárdenas, A., Rojas-Silva, X., Muñoz, L., Leyton, L., Kogan, M.J., Quest, A.F.G. “Gold nanoparticles as tracking devices to shed light on the role of caveolin-1 in early stages of melanoma metastasis”. Nanomedicine (Lond). 2018 Jun;13(12):1447-1462. PubMed Link
  • Lagos, C., Carvajal, P., Castro, I., Jara, D., González, S., Aguilera, S., Barrera, M.J., Quest, A.F.G., Bahamondes, V., Molina, C., Urzúa, U., Hermoso, M.A., Leyton, C., González, M.J. “Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjögren’s syndrome patients”. Clin Immunol. 2018 Jun 9. pii: S1521-6616(18)30348-6. PubMed Link
  • Sepúlveda, D., Barrera, M.J., Castro, I., Aguilera, S., Carvajal, P., Lagos, C., González, S., Albornoz, N., Bahamondes, V., Quest, A.F.G., Urzúa, U., Molina, C., Leyton, C., Hermoso, M.A., González, M.J. “Impaired IRE1α/XBP-1 pathway associated to DNA methylation might contribute to salivary gland dysfunction in Sjögren’s syndrome patients”. Rheumatology (Oxford). 2018 Jun 1;57(6):1021-1032. PubMed Link
  • Inostroza-Riquelme, M., Vivanco, A., Lara, P., Guerrero, S., Salas-Huenuleo, E., Chamorro, A., Leyton, L., Bolaños, K., Araya, E., Quest, A.F.G., Kogan, M.J., Oyarzun-Ampuero, F. “Encapsulation of Gold Nanostructures and Oil-in-Water Nanocarriers in Microgels with Biomedical Potential”. Molecules. 2018 May 18;23(5). pii: E1208. PubMed Link
  • Garrido, M.P., Vera, C., Vega, M., Quest, A.F.G., Romero, C. “Metformin prevents nerve growth factor-dependent proliferative and proangiogenic effects in epithelial ovarian cancer cells and endothelial cells”. Ther Adv Med Oncol. 2018 May 4;10:1758835918770984. PubMed Link
  • Cerda-Opazo, P., Valenzuela-Valderrama, M., Wichmann, I., Rodríguez, A., Contreras-Reyes, D., Fernández, E.A., Carrasco-Aviño, G., Corvalán, A.H., Quest, A.F.G. “Inverse expression of survivin and reprimo correlates with poor patient prognosis in gastric cancer”. Oncotarget. 2018 Feb 5;9(16):12853-12867. PubMed Link
  • Burgos-Bravo, F., Figueroa, N.L., Casanova-Morales, N., Quest, A.F.G., Wilson, C.A.M., Leyton, L. “Single-molecule measurements of the effect of force on Thy-1/αvβ3-integrin interaction using nonpurified proteins”. Mol Biol Cell. 2018 Feb 1;29(3):326-338. PubMed Link
  • Díaz, P., Valenzuela Valderrama, M., Bravo, J., Quest, A.F.G. “Helicobacter pylori and Gastric Cancer: Adaptive Cellular Mechanisms Involved in Disease Progression”. Front Microbiol. 2018 Jan 22;9:5. PubMed Link

2017

  • Oyarce, C., Cruz-Gomez, S., Galvez-Cancino, F., Vargas, P., Moreau, H.D., Diaz-Valdivia, N., Diaz, J., Salazar-Onfray, F.A., Pacheco, R., Lennon-Dumenil, A.M., Quest, A.F.G., Lladser, A. “Caveolin-1 Expression Increases upon Maturation in Dendritic Cells and Promotes Their Migration to Lymph Nodes Thereby Favoring the Induction of CD8+ T Cell Responses”. Front Immunol. 2017 Dec 13;8:1794. PubMed Link
  • Díaz-Valdivia, N.I., Calderón, C.C., Díaz, J.E., Lobos-González, L., Sepulveda, H., Ortíz, R.J., Martinez, S., Silva, V., Maldonado, H.J., Silva, P., Wehinger, S., Burzio, V.A., Torres, V.A., Montecino, M., Leyton, L., Quest, A.F.G.*. “Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells”. Oncotarget. 2017 Dec 5;8(67):111943-111965. PubMed Link
  • Lagos-Cabré, R., Alvarez, A., Kong, M., Burgos-Bravo, F., Cárdenas, A., Rojas-Mancilla, E., Pérez-Nuñez, R., Herrera-Molina, R., Rojas, F., Schneider, P., Herrera-Marschitz, M., Quest, A.F.G., van Zundert, B., Leyton, L. “αVβ3 Integrin regulates astrocyte reactivity”. J Neuroinflammation. 2017 Sep 29;14(1):194. PubMed Link
  • Martin, C., Leyton, L., Hott, M., Arancibia, Y., Spichiger, C., McNiven, M.A., Court, F.A., Concha, M.I., Burgos, P.V., Otth, C. “Herpes Simplex Virus Type 1 Neuronal Infection Perturbs Golgi Apparatus Integrity through Activation of Src Tyrosine Kinase and Dyn-2 GTPase”. Front Cell Infect Microbiol. 2017 Aug 22;7:371. PubMed Link
  • Canales, J., Valenzuela, M., Bravo, J., Cerda-Opazo, P., Jorquera, C., Toledo, H., Bravo, D.*, and Quest, A.F.G.*. “Helicobacter pylori Induced Phosphatidylinositol-3-OH Kinase/mTOR Activation Increases Hypoxia Inducible Factor-1α to Promote Loss of Cyclin D1 and G0/G1 Cell Cycle Arrest in Human Gastric Cells”. Front Cell Infect Microbiol. 2017 Mar 28;7:92. *Corresponding authors (equal contribution). PubMed Link
  • Bravo-Sagua, R., Parra, V., López-Crisosto, C., Díaz, P., Quest, A.F.G., Lavandero S. “Calcium Transport and Signaling in Mitochondria”. Compr Physiol. 2017 Mar 16;7(2):623-634. PubMed Link

2016

  • Maldonado, H., Calderon, C., Burgos-Bravo, F., Kobler, O., Zuschratter, W., Ramirez, O., Härtel, S., Schneider, P., Quest, A.F.G., Herrera-Molina, R.*, Leyton, L.*. “Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway”. BBA-Mol Cell Res. 1864:243-254 (12 November 2016). *Corresponding authors (equal contribution). PubMed Link
  • Bravo-Sagua ,R., López-Crisosto, C., Parra, V., Rodriguez-Peña, M., Rothermel, B.A., Quest, A.F.G. , Lavandero, S. “mTORC1 inhibitor rapamycin and ER stressor tunicamycin induce differential patterns of ERmitochondria coupling”. Scientific Reports 6, Article number: 36394 ( 03 November 2016). PubMed Link
  • Orellana-Manzano, A., O’Ryan, M.G., Lagomarcino, A.J., George, S., Muñoz, M.S., Mamani, N., Serrano, C.A., Harris, P.R., Ramilo, O., Mejías, A., Torres, J.P., Lucero, Y. and Quest, A.F.G. “Helicobacter pylori Infection Is Associated with Decreased Expression of SLC5A8, a Cancer Suppressor Gene, in Young Children”. Front. Cell. Infect. Microbiol., 10 October 2016;6:121. PubMed Link
  • Alvarez, A., Lagos-Cabré, R., Kong, M., Cárdenas, A., Burgos-Bravo, F., Schneider, P., Quest, A.F.G., Leyton, L. “Integrin-mediated transactivation of P2X7R via hemichannel-dependent ATP release stimulates astrocyte migration”. Biochim Biophys Acta. 2016 Sep;1863(9):2175-2188. PubMed Link
  • Riquelme, J.A., Chavez, M.N., Mondaca-Ruff, D., Bustamante, M., Vicencio, J.M., Quest, A.F.G., Lavandero, S. “Therapeutic targeting of autophagy in myocardial infarction and heart failure”. Expert Rev Cardiovasc Ther. 2016 Sep;14(9):1007-1019. PubMed Link
  • Soto, C., Bugueño, I., Hoare, A., Gonzalez, S., Venegas, D., Salinas, D., Melgar-Rodríguez, S., Vernal, R., Gamonal, J., Quest, A.F.G., Pérez-Donoso, J.M., Bravo, D. “The Porphyromonas gingivalis O-antigen is required for inhibition of apoptosis in gingival epithelial cells following bacterial infection”. Version of Record online: 4 NOV 2015. J Periodontal Res. 2016 Aug;51(4):518-528. PubMed Link
  • Ortiz, R., Díaz, J., Díaz, N., Lobos-Gonzalez, L., Cárdenas, A., Contreras, P., Díaz, M.I., Otte, E., Cooper-White, J., Torres, V., Leyton, L. and Quest, A.F.G. “Extracellular matrix-specific Caveolin-1 phosphorylation on tyrosine 14 is linked to augmented melanoma metastasis but not tumorigenesis”. Oncotarget. 2016 May 31. [Epub ahead of print]. PubMed Link
  • Silva, P., Mendoza, P., Rivas, S., Díaz, J., Moraga, C., Quest, A.F.G., Torres, V.A. “Hypoxia promotes Rab5 activation, leading to tumor cell migration, invasion and metastasis”. Oncotarget. 2016 May 17;7(20):29548-29562. PubMed Link
  • Costantino, V.V., Lobos-Gonzalez, L., Ibañez, J., Fernandez, D., Cuello-Carrión, F.D., Valenzuela, M.A., Barbieri, M.A., Semino, S.N., Jahn, G.A., Quest, A.F.G., Lopez, L.A. “Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis”. Cancer Lett. 2016 Mar 1;372(1):10-23. PubMed Link
  • Shaikh, S., Troncoso, R., Criollo, A., Bravo-Sagua, R., Morselli, E., Garcia, L., Cifuentes, M., Quest, A.F.G., Hill, J.A., Lavandero, S. “Regulation of cardiomyocyte autophagy by calcium”. Am J Physiol Endocrinol Metab. 2016 Feb 16. [Epub ahead of print]. PubMed Link
  • Ferreccio, C., Roa, J.C., Bambs, C., Vives, A., Corvalán, A.H., Cortés, S., Foerster, C., Acevedo, J., Huidobro, A., Passi, A. , Toro, P., Covacevich, Y., De la Cruz, R., Koshiol, J., Olivares, M., Miquel, J.F., Cruz, F., Silva, R., Quest, A.F.G., Kogan, M.J., Castro, P.F. and Lavandero, S. “Study protocol for the Maule Cohort (MAUCO) of chronic diseases, Chile 2014–2024”. BMC Public Health 2016 Feb 4;16:122. PubMed Link

2015

  • Valenzuela, M., Canales, J., Corvalán, A., and Quest, A.F.G. “Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis”. World J Gastroenterol. 2015 Dec 7; 21(45): 12742–12756. PubMed Link
  • Sanhueza, C., Wehinger, S., Castillo Bennett, J., Valenzuela, M., Owen, G.I., Quest, A.F.G. “The twisted survivin connection to angiogenesis”. Mol Cancer. 2015 Nov 19;14:198. PubMed Link
  • Silva, P., Soto, N., Díaz, J., Mendoza, P., Díaz, N., Quest, A.F.G., Torres, V.A. “Down-regulation of Rab5 decreases characteristics associated with maintenance of cell transformation”. Biochem Biophys Res Commun. 2015 Aug 21;464(2):642-646. PubMed Link
  • López-Crisosto, C., Bravo-Sagua, R., Rodriguez-Peña, M., Mera, C., Castro, P.F., Quest, A.F.G., Rothermel, B.A., Cifuentes, M., Lavandero, S. “ER-to-mitochondria miscommunication and metabolic diseases”. Biochim Biophys Acta. 2015 Oct;1852:2096-2105. PubMed Link
  • Diaz-Valdivia, N., Bravo, D., Huerta, H., Henriquez, S., Gabler, F., Vega, M., Romero, C., Calderon, C., Owen, G.I., Leyton, L. and Quest, A.F.G. “Enhanced caveolin-1 expression increases migration, anchorage-independent growth and invasion of endometrial adenocarcinoma cells”. BMC Cancer. 2015 Jun 10;15:463. PubMed Link
  • Barrera, M.J., Aguilera, S., Veerman, E., Quest, A.F.G., Díaz-Jiménez, D., Urzúa, U., Cortés, J., González, S., Castro, I., Molina, C., Bahamondes, V., Leyton, C., Hermoso, M.A., González, M.J. “Salivary mucins induce a Toll-like receptor 4-mediated pro-inflammatory response in human submandibular salivary cells: are mucins involved in Sjögren’s syndrome?”. Rheumatology (Oxford). 2015 Aug;54(8):1518-1527. PubMed Link
  • Wehinger, S., Ortiz, R., Díaz, M.I., Aguirre, A., Valenzuela, M., Llanos, P., Mc Master, C., Leyton, L., Quest, A.F.G. “Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells”. Biochim Biophys Acta. 2015 May;1852(5):693-708. PubMed Link
  • Barrientos, G., Llanos, P., Hidalgo, J., Bolaños, P., Caputo, C., Riquelme, A., Sánchez, G., Quest, A.F.G., Hidalgo, C. “Cholesterol removal from adult skeletal muscle impairs excitation-contraction coupling and aging reduces caveolin-3 and alters the expression of other triadic proteins”. Front Physiol. 2015 Apr 10;6:105. PubMed Link
  • Sung, H.H., Castro, I., González, S., Aguilera, S., Smorodinsky, N.I., Quest, A.F.G, Bahamondes, V., Alliende, C., Cortés, J., Molina, C., Urzúa, U., Barrera, M.J., Hermoso, M., Herrera, L., Leyton, C., González, M.J. “MUC1/SEC and MUC1/Y overexpression is associated with inflammation in Sjögren’s syndrome”. Oral Dis. 2015 Sep;21(6):730-738. PubMed Link