2020-2023

2023

  • Valdivia, A.D.*, Ávalos, A.M., Leyton, L.* “Thy-1(CD90)-regulated cell adhesion and migration of mesenchymal cells: Insights into Adhesomes, Mechanical Forces, and Signaling Pathways.”. Front. Cell Dev. Biol.; Sec. Cell Adhesion and Migration, Volume 11 – 2023. *Corresponding authors (equal contribution). Accepted on September 25th, 2023. Abstract´s Open Access Link
  • Maldonado H., Leyton, L. “CSK-mediated signalling by integrins in cancer”. Front Cell Dev Biol. 2023 Jul 7;11:1214787. PubMed Link – Open Access Link
  • Palacios, E., Lobos-González, L., Guerrero, S., Kogan, M.J., Shao, B., Heinecke, J.W., Quest, A.F.G., Leyton, L., Valenzuela-Valderrama, M. “Helicobacter pylori outer membrane vesicles induce astrocyte reactivity through nuclear factor-κappa B activation and cause neuronal damage in vivo in a murine model”. J Neuroinflammation. 2023 Mar 9;20(1):66. PubMed Link – Open Access Link – Springer Link
  • Pérez-Núñez, R., Chamorro, A., González, M.F., Contreras, P, Artigas, R., Corvalán, A.H., van Zundert, B., Reyes, C., Moya, P.R., Avalos, A.M., Schneider, P., Quest, A.F.G. & Leyton, L. “Protein kinase B (AKT) upregulation and Thy-1-αvβ3 integrin-induced phosphorylation of Connexin43 by activated AKT in astrogliosis”. J Neuroinflammation. 2023 Jan 6;20(1):5. PubMed Link – Open Access Link – Springer Link
  • Sanhueza, S., Simón, L., Cifuentes, M., Quest, A.F.G. “The Adipocyte–Macrophage Relationship in Cancer: A Potential Target for Antioxidant Therapy”. Antioxidants. 2023 Jan 4;12(1), 126. PubMed Link – Open Access Link

2022

  • Díaz-Vesga, M.C., Flores-Vergara, R., Riquelme, J.A., Llancaqueo, M., Sánchez, G., Vergara, C., Michea, L., Donoso, P., Quest, A.F.G., Olmedo, I., Pedrozo, Z. “Polycystin-1 Is a Crucial Regulator of BIN1 Expression and T-Tubule Remodeling Associated with the Development of Dilated Cardiomyopathy.”. Int J Mol Sci. 2022 Dec 30;24(1):667. PubMed Link – Open Access Link
  • Pérez, L.A., León, J., López, J., Rojas, D., Reyes, M., Contreras, P., Quest, A.F.G., Escudero, C., Leyton, L. “The GPI-Anchored Protein Thy-1/CD90 Promotes Wound Healing upon Injury to the Skin by Enhancing Skin Perfusion”. Int J Mol Sci. 2022 Oct 19;23(20):12539. PubMed Link – Open Access Link
  • González, M.F., Burgos-Ravanal, R., Shao, B., Heinecke, J., Valenzuela-Valderrama, M., Corvalán, A.H., Quest, A.F.G. “Extracellular vesicles from gastric epithelial GES-1 cells infected with Helicobacter pylori promote changes in recipient cells associated with malignancy.”. Front Oncol. 2022 Oct 12;12:962920. PubMed Link – Open Access Link
  • Soto, C., Rojas, V., Yáñez, L., Hidalgo, A., Olivera, M., Pacheco, M., Venegas, D., Salinas, D., Bravo, D., Quest, A.F.G. “Porphyromonas gingivalis-Helicobacter pylori co-incubation enhances Porphyromonas gingivalis virulence and increases migration of infected human oral keratinocytes”. J Oral Microbiol. 2022 Aug 12;14(1):2107691. PubMed Link
  • Díaz-Valdivia, N., Simón, L., Díaz, J., Martinez-Meza, S., Contreras, P., Burgos-Ravanal, R., Pérez, V.I., Frei, B., Leyton, L., Quest, A.F.G. “Mitochondrial Dysfunction and the Glycolytic Switch Induced by Caveolin-1 Phosphorylation Promote Cancer Cell Migration, Invasion, and Metastasis”. Cancers (Basel). 2022 Jun 10;14(12):2862. PubMed Link – Open Access Link
  • Hu, P., Leyton, L., Hagood, J.S., Barker, T.H. “Thy-1-Integrin Interactions in cis and Trans Mediate Distinctive Signaling”. Front Cell Dev Biol. 2022 Jun 6;10:928510. PubMed Link – Open Access Link
  • Simón, L., Sanhueza, S., Gaete-Ramírez, B., Varas-Godoy, M., Quest, A.F.G. “Role of the Pro-Inflammatory Tumor Microenvironment in Extracellular Vesicle-Mediated Transfer of Therapy Resistance”. Front Oncol. 2022 May 11;12:897205. PubMed Link – Open Access Link
  • Castro, I., Carvajal, P., Jara, D., Aguilera, S., Heathcote, B., Barrera, M.J., Aliaga-Tobar, V., Maracaja-Coutinho, V., Urzúa, U., Quest, A.F.G., González, S., Molina, C., Hermoso, M., González, M.J. “Small RNA Expression Profiling Reveals hsa-miR-181d-5p Downregulation Associated With TNF-α Overexpression in Sjögren’s Syndrome Patients”. Front Immunol. 2022 Apr 1;13:870094. PubMed Link – Open Access Link
  • Arrua, E.C., Sanchez, S.V., Trincado, V., Hidalgo, A., Quest, A.F.G., Morales, J.O. “Experimental design and optimization of a novel dual-release drug delivery system with therapeutic potential against infection with Helicobacter pylori”. Colloids Surf B Biointerfaces. 2022 Feb 11;213:112403. Open Access Link
  • Pérez, L.A., Leyton, L., Valdivia, A. “Thy-1 (CD90), Integrins and Syndecan 4 are Key Regulators of Skin Wound Healing”. Front. Cell Dev. Biol. 2022 Feb 03;10:810474. PubMed Link – Open Access Link

2021

  • Pérez, L.A., Rashid, A., Combs, J.D., Schneider, P., Rodríguez, A., Salaita, K. and Leyton, L. “An Outside-In Switch in Integrin Signaling Caused by Chemical and Mechanical Signals in Reactive Astrocytes”. Front. Cell Dev. Biol. 2021 Aug 23;9:712627. PubMed Link – Open Access Link
  • Zárate, A.M., Espinosa-Bustos, C., Guerrero, S., Fierro, A., Oyarzún-Ampuero, F., Quest, A.F.G., Di Marcotullio, L., Loricchio, E., Caimano, M., Calcaterra, A., González-Quiroz, M., Aguirre, A., Meléndez, J., Salas, C.O. “A New Smoothened Antagonist Bearing the Purine Scaffold Shows Antitumour Activity In Vitro and In Vivo”. Int J Mol Sci. 2021 Aug 4;22(16):8372. PubMed Link – Open Access Link
  • Burgos-Ravanal, R., Campos, A., Díaz-Vesga, M.C., González, M.F., León, D., Lobos-González, L., Leyton, L., Kogan, M.J., Quest, A.F.G. “Extracellular Vesicles as Mediators of Cancer Disease and as Nanosystems in Theranostic Applications”. Cancers (Basel). 2021 Jul 2;13(13):3324. PubMed Link – Open Access Link
  • González, M.F., Díaz, P., Sandoval-Bórquez, A., Herrera, D., Quest, A.F.G. “Helicobacter pylori Outer Membrane Vesicles and Extracellular Vesicles from Helicobacter pylori-Infected Cells in Gastric Disease Development”. Int J Mol Sci. 2021 May 1;22(9):4823. PubMed Link – Open Access Link
  • Díaz, P., Sandoval-Bórquez, A., Bravo-Sagua, R., Quest, A.F.G., Lavandero, S. “Perspectives on Organelle Interaction, Protein Dysregulation, and Cancer Disease”. Front Cell Dev Biol. 2021 Feb 25;9:613336. PubMed Link – Open Access Link
  • Brenet, M., Martínez, S., Pérez-Nuñez, R., Pérez, L.A., Contreras, P., Díaz, J., Avalos, A.M., Schneider, P., Quest, A.F.G. and Leyton, L. “Thy-1 (CD90)-Induced Metastatic Cancer Cell Migration and Invasion Are β3 Integrin-Dependent and Involve a Ca2+/P2X7 Receptor Signaling Axis”. Front. Cell Dev. Biol. 2021 Jan 12;8:592442. PubMed Link – Open Access Link
  • Díaz, P., Román, A., Carrasco-Aviño, G., Rodríguez, A., Corvalán, A.H., Lavandero, S. and Quest, A.F.G. “Helicobacter Pylori Infection Triggers PERK-Associated Survivin Loss in Gastric Tissue Samples and Cell Lines”. J Cancer Sci Clin Ther 2021; 5 (1): 063-082. Open Access Link

2020

  • Rivas, S., Silva, P., Reyes, M., Sepúlveda, H., Solano, L., Acuña, J., Guerrero, M., Varas-Godoy, M., Quest, A.F.G., Montecino, M., Torres, V.A. “The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells”. Sci Rep. 2020 Dec 18;10(1):22302.
    PubMed Link – Open Access Link
  • Lara, P., Chan, A.B., Cruz, L.J., Quest, A.F.G., Kogan, M.J. “Exploiting the Natural Properties of Extracellular Vesicles in Targeted Delivery towards Specific Cells and Tissues”. Pharmaceutics. 2020 Oct 26;12(11):1022. PubMed Link – Open Access Link
  • Garrido, M.P., Salvatierra, R., Valenzuela-Valderrama, M., Vallejos, C., Bruneau, N., Hernández, A., Vega, M., Selman, A., Quest, A.F.G., Romero, C. “Metformin Reduces NGF-Induced Tumour Promoter Effects in Epithelial Ovarian Cancer Cells”. Pharmaceuticals (Basel). 2020 Oct 16;13(10):315. PubMed Link – Open Access Link
  • Orellana-Serradell, O., Díaz, M.C., González, M.F., Gutiérrez, M., Herrera, D., Jara, D., Maureira, D., Ruiz-Fuentes, J.L., Sanhueza, Leyton, L. “Does Peer Reviewing for COVID-19-Related Papers Still Work?”. Front. Res. Metr. Anal., 08 October 2020. Open Access Link – Sbcch Link – News Link
  • Burgos-Bravo, F., Martínez-Meza, S., Quest, A.F.G., Wilson, C.A.M. and Leyton, L. “Application of Force to a Syndecan-4 Containing Complex With Thy-1–αVβ3 Integrin Accelerates Neurite Retraction”. Front. Mol. Biosci., 29 September 2020. Open Access Link
  • Sanhueza, C., Castillo-Bennett, J., Valenzuela-Valderrama, M., Contreras-Orellana, P., Lobos-González, L., Campos, A., Wehinger, S., Lladser, A., Kiessling, R., Leyton, L., Quest, A.F.G. “Caveolin-1-Mediated Tumor Suppression Is Linked to Reduced HIF1α S-Nitrosylation and Transcriptional Activity in Hypoxia”. Cancers 2020;12(9), 2349. 2020 Aug 20. Open Access Link
  • Valdivia, A., Cárdenas, A., Brenet, M., Maldonado, H., Kong. M., Díaz, J., Burridge, K., Schneider, P., San Martín, A., García-Mata, R., Quest, A.F.G., Leyton, L. “Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells”. Cell Communication and Signaling. 2020 Aug 18;18(1):129. PubMed Link – Open Access Link – News Link
  • Díaz, M.I., Díaz, P., Castillo Bennett, J., Urra, H., Ortiz, R., Contreras-Orellana, P., Hetz, C., Quest, A.F.G. “Caveolin-1 suppresses tumor formation through the inhibition of the unfolded protein response”. Cell Death and Disease. 2020 Aug 03;11:648. PubMed Link – Open Access Link
  • Lillo, P., Núñez, O., Castro-Sepúlveda, M., Torres-Quintana, M.A., Lladser, A., Quest, A.F.G., Espinoza, C., Llanos, P., Wehinger, S. “Loss of Caveolin-1 Is Associated with a Decrease in Beta Cell Death in Mice on a High Fat Diet”. Int J Mol Sci. 2020 Jul 23;21(15):E5225. PubMed Link
  • Palavecino, C.E., Carrasco-Véliz, N., Quest, A.F.G., Garrido, M.P., Valenzuela-Valderrama, M. “The 5′ untranslated region of the anti-apoptotic protein Survivin contains an inhibitory upstream AUG codon”. Biochem Biophys Res Commun. 2020 Apr 9. pii: S0006-291X(20)30658-6. PubMed Link
  • Simón, L., Campos, A., Leyton, L. & Quest, A.F.G. “Caveolin-1 function at the plasma membrane and in intracellular compartments in cancer”. Cancer Metastasis Rev 39, 435–453. 2020 May 27. Open Access Link – News Link
  • Ortiz, R., Díaz, J., Díaz-Valdivia, N., Martínez, S., Simón, L., Contreras-Orellana, P., Lobos-González, L., Guerrero, S., Leyton, L., Quest, A.F.G. “Src-family kinase inhibitors block early steps of caveolin-1-enhanced lung metastasis by melanoma cells”. Biochem Pharmacol. 2020 Mar 30;177:113941. PubMed Link
  • Ferreccio, C., Huidobro, A., Cortés, S., Bambs, C., Toro, P., Van De Wyngard, V., Acevedo, J., Paredes, F., Venegas, P., Verdejo, H., Oyarzún-González, X., Cook, P., Castro, P.F., Foerster, C., Vargas, C., Koshiol, J., Araya, J.C., Cruz, F., Corvalán, A.H., Quest A.F., Kogan, M.J., Lavandero, S., MAUCO Study Group. “Cohort Profile: The Maule Cohort (MAUCO)”. Int J Epidemiol. 2020 Mar 16. pii: dyaa003. PubMed Link
  • Díaz-Valdivia, N.I., Díaz, J., Contreras-Orellana, P., Campos, A., Rojas-Celis, V., Burgos-Ravanal, R.A., Lobos-González, L., Torres, V.A., Perez, V.I., Frei, B., Leyton, L., Quest, A.F.G. “The non-receptor tyrosine phosphatase type 14 blocks caveolin-1-enhanced cancer cell metastasis”. Oncogene. 2020 Mar 9. Sbcch Link – PubMed Link
  • Villa, M., Cerda-Opazo, P., Jimenez-Gallegos, D., Garrido-Moreno, V., Chiong, M., Quest, A.F., Toledo, J., Garcia, L. “Pro-fibrotic effect of oxidized LDL in cardiac myofibroblasts”. Biochem Biophys Res Commun. 2020 Apr 9;524(3):696-701. Epub 2020 Feb 6. PubMed Link
  • Lara, P., Palma-Florez, S., Salas-Huenuleo, E., Polakovicova, I., Guerrero, S., Lobos-Gonzalez, L., Campos, A., Muñoz, L., Jorquera-Cordero, C., Varas-Godoy, M., Cancino, J., Arias, E., Villegas, J., Cruz, L.J., Albericio, F., Araya, E., Corvalan, A.H., Quest, A.F.G., Kogan, M.J. “Gold nanoparticle based double-labeling of melanoma extracellular vesicles to determine the specificity of uptake by cells and preferential accumulation in small metastatic lung tumors”. J Nanobiotechnology. 2020 Jan 23;18(1):20. PubMed Link
  • Lagos-Cabré, R., Burgos-Bravo, F., Avalos, A.M., Leyton, L. “Connexins in Astrocyte Migration”. Front Pharmacol. 2020 Jan 15;10:1546. PubMed Link