If someone brings up the topic of neuroscience, or the nervous system, several cells or molecules might come to your mind. The scrawny neurons within the brain, connected to their neighbours in an unfathomably complex network. Or the neurotransmitters sent by neurons as signals, with famous faces like dopamine or serotonin. However, one cell you likely wouldn’t mention is the astrocyte.
Reactive astrocytes help to form the glial scar. Once the scar has formed, astrocytes settle at the scar,
permanently becoming a non-motile scar astrocyte [Front Pharmacol. 10:1546 (2020)].
ECM, extracellular matrix; GF, growth factors; CSPG, chondroitin sulfate proteoglycans.
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