2010 – 2019

2019

  • Garrido, M.P., Hurtado, I., Valenzuela-Valderrama, M., Salvatierra, R., Hernández, A., Vega, M., Selman, A., Quest, A.F.G., Romero, C. “NGF-Enhanced Vasculogenic Properties of Epithelial Ovarian Cancer Cells Is Reduced by Inhibition of the COX-2/PGE2 Signaling Axis”. Cancers (Basel). 2019 Dec 7;11(12). pii: E1970. PubMed Central – Open Access
  • Martínez-Meza, S., Díaz, J., Sandoval-Bórquez, A., Valenzuela-Valderrama, M., Díaz-Valdivia, N., Rojas-Celis, V., Contreras-Orellana, P., Huilcaman, R., Ocaranza, M.P., Chiong, M., Leyton, L., Lavandero, S., Quest, A.F.G. “AT2 Receptor Mediated Activation of the Tyrosine Phosphatase PTP1B Blocks Caveolin-1 Enhanced Migration, Invasion and Metastasis of Cancer Cells”. Cancers (Basel). 2019 Sep 3;11(9). pii: E1299. PubMed Central – Open Access
  • Alcaraz, J., Carrasco, J.L., Millares, L., Luis, I.C., Fernández-Porras, F.J., Martínez-Romero, A., Diaz-Valdivia, N., De Cos, J.S., Rami-Porta, R., Seijo, L., Ramírez, J., Pajares, M.J., Reguart, N., Barreiro, E., Monsó, E. “Stromal markers of activated tumor associated fibroblasts predict poor survival and are associated with necrosis in non-small cell lung cancer”. Lung Cancer. 2019 Sep;135:151-160. Epub 2019 Jul 24. PubMed Abstract – Lung Cancer (Elsevier)
  • Felley-Bosco, Leyton, L. “Editorial: Thy1/CD90 Surface Glycoprotein: Sensor of Microenvironment?”. Front Cell Dev Biol. 2019 Aug 13;7:162. PubMed Central – Open Access
  • Arce, M., Pinto, M.P., Galleguillos, M., Muñoz, C., Lange, S., Ramirez, C., Erices, R., Gonzalez, P., Velasquez, E., Tempio, F., Lopez, M.N., Salazar-Onfray, F., Cautivo, K., Kalergis, A.M., Cruz, S., Lladser, Á., Lobos-González, L., Valenzuela, G., Olivares, N., Sáez, C., Koning, T., Sánchez, F.A., Fuenzalida, P., Godoy, A., Contreras-Orellana, P., Leyton, L., Lugano, R., Dimberg, A., Quest, A.F.G., Owen, G.I. “Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation”. Cancers (Basel). 2019 Aug 2;11(8). pii: E1103. PubMed Central – Open Access
  • Campos, A., Burgos-Ravanal, R., González, M.F., Huilcaman, R., Lobos González, L., Quest, A.F.G. “Cell Intrinsic and Extrinsic Mechanisms of Caveolin-1-Enhanced Metastasis”. Biomolecules. 2019 Jul 29;9(8). pii: E314. PubMed Central – Open Access – LabComCel News
  • Leyton, L., Díaz, J., Martínez, S., Palacios, E., Pérez, L.A., Pérez, R.D. “Thy-1/CD90 a Bidirectional and Lateral Signaling Scaffold”. Front Cell Dev Biol. 2019 Jul 26;7:132. PubMed Central – Open Access
  • Bravo-Sagua, R., Parra, V., Ortiz-Sandoval, C., Navarro-Marquez, M., Rodríguez, A.E., Diaz-Valdivia, N., Sanhueza, C., Lopez-Crisosto, C., Tahbaz, N., Rothermel, B.A., Hill, J.A., Cifuentes, M., Simmen, T., Quest, A.F.G.*, Lavandero, S.* “Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER-mitochondria communication during the early phase of ER stress”. Cell Death Differ. 2019 Jul;26(7):1195-1212. Epub 2018 Sep 12. *Corresponding authors (equal contribution). PubMed Central – Open Access
  • Villamizar-Sarmiento, M.G., Moreno-Villoslada, I., Martínez, S., Giacaman, A., Miranda, V., Vidal, A., Orellana, S.L., Concha, M., Pavicic, F., Lisoni, J.G., Leyton, L., Oyarzun-Ampuero, F.A. “Ionic Nanocomplexes of Hyaluronic Acid and Polyarginine to Form Solid Materials: A Green Methodology to Obtain Sponges with Biomedical Potential”. Nanomaterials (Basel). 2019 Jun 29;9(7). pii: E944. PubMed Central – Open Access
  • Bravo, J., Díaz, P., Corvalán, A.H., Quest, A.F.G. “A Novel Role for Helicobacter pylori Gamma-Glutamyltranspeptidase in Regulating Autophagy and Bacterial Internalization in Human Gastric Cells”. Cancers (Basel). 2019 Jun 10;11(6). pii: E801. PubMed Central – Open Access
  • Valenzuela-Valderrama, M., Cerda-Opazo, P., Backert, S., González, M.F., Carrasco-Véliz, N., Jorquera-Cordero, C., Wehinger, S., Canales, J., Bravo, D., Quest, A.F.G. “The Helicobacter pylori Urease Virulence Factor Is Required for the Induction of Hypoxia-Induced Factor-1α in Gastric Cells”. Cancers (Basel). 2019 Jun 10;11(6). pii: E799. PubMed Central – Open Access

2018

  • Guerrero, S., Inostroza-Riquelme, M., Contreras-Orellana, P., Diaz-Garcia, V., Lara, P., Vivanco-Palma, A., Cárdenas, A., Miranda, V., Robert, P., Leyton, L., Kogan, M.J., Quest A.F.G., Oyarzun-Ampuero, F. “Curcumin-loaded nanoemulsion: a new safe and effective formulation to prevent tumor reincidence and metastasis”. Nanoscale. 2018 Dec 21;10(47):22612-22622. PubMed Abstract – Nanoscale (Royal Society of Chemistry)
  • Díaz-García, V.M., Guerrero, S., Díaz-Valdivia, N., Lobos-González, L., Kogan, M., Pérez-Donoso, J.M., Quest, A.F.G. “Biomimetic quantum dot-labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung metastasis by in vivo imaging”. Int J Nanomedicine. 2018 Oct 16;13:6391-6412. PubMed Central – Open Access
  • Campos, A., Salomon, C., Bustos, R., Díaz, J., Martínez, S., Silva, V., Reyes, C., Díaz-Valdivia, N., Varas-Godoy, M., Lobos-González, L., Quest, A.F.G. “Caveolin-1-containing extracellular vesicles transport adhesion proteins and promote malignancy in breast cancer cell lines”. Nanomedicine (Lond). 2018 Oct;13(20):2597-2609. PubMed Abstract – Nanomedicine
  • Castillo Bennett, J., Silva, P., Martinez, S., Torres, V.A., Quest, A.F.G. “Hypoxia-Induced Caveolin-1 Expression Promotes Migration and Invasion of Tumor Cells”. Curr Mol Med. 2018;18(4):199-206. PubMed Central
  • Peña-Oyarzun, D., Bravo-Sagua, R., Diaz-Vega, A., Aleman, L., Chiong, M., Garcia, L., Bambs, C., Troncoso, R., Cifuentes, M., Morselli, E., Ferreccio, C., Quest, A.F.G., Criollo, A., Lavandero, S. “Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?”. Free Radic Biol Med. 2018 Aug 20;124:61-78. PubMed Central
  • Bravo, D., Hoare, A., Soto, C., Valenzuela, M.A., Quest, A.F.G. “Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects”. World J Gastroenterol. 2018 Jul 28;24(28):3071-3089. PubMed Central
  • Lagos-Cabré, R., Brenet, M., Díaz, J., Pérez, R.D., Pérez, L.A., Herrera-Molina, R., Quest, A.F.G., Leyton, L. “Intracellular Ca2+ Increases and Connexin 43 Hemichannel Opening Are Necessary but Not Sufficient for Thy-1-Induced Astrocyte Migration.”. Int J Mol Sci. 2018 Jul 26;19(8). PubMed Central
  • Guerrero, S., Díaz-García, V.M., Contreras-Orellana, P., Lara, P., Palma, S., Guzman, F., Lobos-Gonzalez, L., Cárdenas, A., Rojas-Silva, X., Muñoz, L., Leyton, L., Kogan, M.J., Quest, A.F.G. “Gold nanoparticles as tracking devices to shed light on the role of caveolin-1 in early stages of melanoma metastasis”. Nanomedicine (Lond). 2018 Jun;13(12):1447-1462. PubMed Central
  • Lagos, C., Carvajal, P., Castro, I., Jara, D., González, S., Aguilera, S., Barrera, M.J., Quest, A.F.G., Bahamondes, V., Molina, C., Urzúa, U., Hermoso, M.A., Leyton, C., González, M.J. “Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjögren’s syndrome patients”. Clin Immunol. 2018 Jun 9. pii: S1521-6616(18)30348-6. PubMed Central
  • Sepúlveda, D., Barrera, M.J., Castro, I., Aguilera, S., Carvajal, P., Lagos, C., González, S., Albornoz, N., Bahamondes, V., Quest, A.F.G., Urzúa, U., Molina, C., Leyton, C., Hermoso, M.A., González, M.J. “Impaired IRE1α/XBP-1 pathway associated to DNA methylation might contribute to salivary gland dysfunction in Sjögren’s syndrome patients”. Rheumatology (Oxford). 2018 Jun 1;57(6):1021-1032. PubMed Central
  • Inostroza-Riquelme, M., Vivanco, A., Lara, P., Guerrero, S., Salas-Huenuleo, E., Chamorro, A., Leyton, L., Bolaños, K., Araya, E., Quest, A.F.G., Kogan, M.J., Oyarzun-Ampuero, F. “Encapsulation of Gold Nanostructures and Oil-in-Water Nanocarriers in Microgels with Biomedical Potential”. Molecules. 2018 May 18;23(5). pii: E1208. PubMed Central
  • Garrido, M.P., Vera, C., Vega, M., Quest, A.F.G., Romero, C. “Metformin prevents nerve growth factor-dependent proliferative and proangiogenic effects in epithelial ovarian cancer cells and endothelial cells”. Ther Adv Med Oncol. 2018 May 4;10:1758835918770984. PubMed Central
  • Cerda-Opazo, P., Valenzuela-Valderrama, M., Wichmann, I., Rodríguez, A., Contreras-Reyes, D., Fernández, E.A., Carrasco-Aviño, G., Corvalán, A.H., Quest, A.F.G. “Inverse expression of survivin and reprimo correlates with poor patient prognosis in gastric cancer”. Oncotarget. 2018 Feb 5;9(16):12853-12867. PubMed Central
  • Burgos-Bravo, F., Figueroa, N.L., Casanova-Morales, N., Quest, A.F.G., Wilson, C.A.M., Leyton, L. “Single-molecule measurements of the effect of force on Thy-1/αvβ3-integrin interaction using nonpurified proteins”. Mol Biol Cell. 2018 Feb 1;29(3):326-338. PubMed Central
  • Díaz, P., Valenzuela Valderrama, M., Bravo, J., Quest, A.F.G. “Helicobacter pylori and Gastric Cancer: Adaptive Cellular Mechanisms Involved in Disease Progression”. Front Microbiol. 2018 Jan 22;9:5. PubMed Central

2017

  • Oyarce, C., Cruz-Gomez, S., Galvez-Cancino, F., Vargas, P., Moreau, H.D., Diaz-Valdivia, N., Diaz, J., Salazar-Onfray, F.A., Pacheco, R., Lennon-Dumenil, A.M., Quest, A.F.G., Lladser, A. “Caveolin-1 Expression Increases upon Maturation in Dendritic Cells and Promotes Their Migration to Lymph Nodes Thereby Favoring the Induction of CD8+ T Cell Responses”. Front Immunol. 2017 Dec 13;8:1794. PubMed Central – Frontiers in Immunology
  • Díaz-Valdivia, N.I., Calderón, C.C., Díaz, J.E., Lobos-González, L., Sepulveda, H., Ortíz, R.J., Martinez, S., Silva, V., Maldonado, H.J., Silva, P., Wehinger, S., Burzio, V.A., Torres, V.A., Montecino, M., Leyton, L., Quest, A.F.G.*. “Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells”. Oncotarget. 2017 Dec 5;8(67):111943-111965. PubMed Central – Open Access
  • Lagos-Cabré, R., Alvarez, A., Kong, M., Burgos-Bravo, F., Cárdenas, A., Rojas-Mancilla, E., Pérez-Nuñez, R., Herrera-Molina, R., Rojas, F., Schneider, P., Herrera-Marschitz, M., Quest, A.F.G., van Zundert, B., Leyton, L. “αVβ3 Integrin regulates astrocyte reactivity”. J Neuroinflammation. 2017 Sep 29;14(1):194. PubMed Central
  • Lopez-Crisosto, C., Pennanen, C., Vasquez-Trincado, C., Morales, P.E., Bravo-Sagua, R., Quest, A.F.G., Chiong, M., Lavandero, S. “Sarcoplasmic reticulum-mitochondria communication in cardiovascular pathophysiology”. Nat Rev Cardiol. 2017 Jun;14(6):342-360. PubMed Central
  • Canales, J., Valenzuela, M., Bravo, J., Cerda-Opazo, P., Jorquera, C., Toledo, H., Bravo, D.*, and Quest, A.F.G.*. “Helicobacter pylori Induced Phosphatidylinositol-3-OH Kinase/mTOR Activation Increases Hypoxia Inducible Factor-1α to Promote Loss of Cyclin D1 and G0/G1 Cell Cycle Arrest in Human Gastric Cells”. Front Cell Infect Microbiol. 2017 Mar 28;7:92. *Corresponding authors (equal contribution). PubMed Central
  • Bravo-Sagua, R., Parra, V., López-Crisosto, C., Díaz, P., Quest, A.F.G., Lavandero S. “Calcium Transport and Signaling in Mitochondria”. Biochim Biophys Acta Mol Cell Res. 2017 Feb;1864(2):243-254. PubMed Central
  • Maldonado, H., Calderon, C., Burgos-Bravo, F., Kobler, O., Zuschratter, W., Ramirez, O., Härtel, S., Schneider, P., Quest, A.F.G., Herrera-Molina, R.*, Leyton, L.*. “Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway”. Compr Physiol. 2017 Mar 16;7(2):623-634. *Corresponding authors (equal contribution). PubMed Central

2016

  • Barrera, M.J., Aguilera, S., Castro, I., Cortés, J., Bahamondes, V., Quest, A.F.G., Molina, C., González, S., Hermoso, M., Urzúa, U., Leyton, C., González, M.J. “Pro-inflammatory cytokines enhance ERAD and ATF6α pathway activity in salivary glands of Sjögren’s syndrome patients”. J Autoimmun. 2016 Dec;75:68-81. PubMed Central
  • Bravo-Sagua ,R., López-Crisosto, C., Parra, V., Rodriguez-Peña, M., Rothermel, B.A., Quest, A.F.G. , Lavandero, S. “mTORC1 inhibitor rapamycin and ER stressor tunicamycin induce differential patterns of ER-mitochondria coupling”. Sci Rep. 2016 Nov 3;6:36394. PubMed Central
  • Orellana-Manzano, A., O’Ryan, M.G., Lagomarcino, A.J., George, S., Muñoz, M.S., Mamani, N., Serrano, C.A., Harris, P.R., Ramilo, O., Mejías, A., Torres, J.P., Lucero, Y. and Quest, A.F.G. “Helicobacter pylori Infection Is Associated with Decreased Expression of SLC5A8, a Cancer Suppressor Gene, in Young Children”. Front Cell Infect Microbiol. 2016 Oct 10;6:121. PubMed Central
  • Alvarez, A., Lagos-Cabré, R., Kong, M., Cárdenas, A., Burgos-Bravo, F., Schneider, P., Quest, A.F.G., Leyton, L. “Integrin-mediated transactivation of P2X7R via hemichannel-dependent ATP release stimulates astrocyte migration”. Biochim Biochim Biophys Acta. 2016 Sep;1863(9):2175-88. PubMed Central
  • Riquelme, J.A., Chavez, M.N., Mondaca-Ruff, D., Bustamante, M., Vicencio, J.M., Quest, A.F.G., Lavandero, S. “Therapeutic targeting of autophagy in myocardial infarction and heart failure”. Expert Rev Cardiovasc Ther. 2016 Sep;14(9):1007-19. PubMed Central
  • Soto, C., Bugueño, I., Hoare, A., Gonzalez, S., Venegas, D., Salinas, D., Melgar-Rodríguez, S., Vernal, R., Gamonal, J., Quest, A.F.G., Pérez-Donoso, J.M., Bravo, D. “The Porphyromonas gingivalis O-antigen is required for inhibition of apoptosis in gingival epithelial cells following bacterial infection”. J Periodontal Res. 2016 Aug;51(4):518-28. PubMed Central
  • Ortiz, R., Díaz, J., Díaz, N., Lobos-Gonzalez, L., Cárdenas, A., Contreras-Orellana, P., Díaz, M.I., Otte, E., Cooper-White, J., Torres, V., Leyton, L., Quest, A.F.G. “Extracellular matrix-specific Caveolin-1 phosphorylation on tyrosine 14 is linked to augmented melanoma metastasis but not tumorigenesis”. Oncotarget. 2016 Jun 28;7(26):40571-40593. PubMed Central
  • Navarrete, M., Hott, M., Caroca, J., Leyton, L., Venegas, N., Ismail, K., Saavedra, F., Otth, C. “Correlation between clinical and laboratory criteria of suspected Hantavirus cases and the results of the reference diagnostic technique”. Rev Chilena Infectol. 2016 Jun;33(3):275-81. [Article in Spanish] PubMed Central
  • Silva, P., Mendoza, P., Rivas, S., Díaz, J., Moraga, C., Quest, A.F.G., Torres, V.A. “Hypoxia promotes Rab5 activation, leading to tumor cell migration, invasion and metastasis”. Oncotarget. 2016 May 17;7(20):29548-62. PubMed Central
  • Shaikh, S., Troncoso, R., Criollo, A., Bravo-Sagua, R., Garcia, L., Morselli, E., Cifuentes, M., Quest, A.F.G., Hill, J.A., Lavandero, S. “Regulation of cardiomyocyte autophagy by calcium”. Am J Physiol Endocrinol Metab. 2016 Apr 15;310(8):E587-E596. PubMed Central
  • Costantino, V.V., Lobos-Gonzalez, L., Ibañez, J., Fernandez, D., Cuello-Carrión, F.D., Valenzuela, M.A., Barbieri, M.A., Semino, S.N., Jahn, G.A., Quest, A.F.G., Lopez, L.A. “Dehydroleucodine inhibits tumor growth in a preclinical melanoma model by inducing cell cycle arrest, senescence and apoptosis”. Cancer Lett. 2016 Mar 1;372(1):10-23. PubMed Central
  • Ferreccio, C., Roa, J.C., Bambs, C., Vives, A., Corvalán, A.H., Cortés, S., Foerster, C., Acevedo, J., Huidobro, A., Passi, A. , Toro, P., Covacevich, Y., De la Cruz, R., Koshiol, J., Olivares, M., Miquel, J.F., Cruz, F., Silva, R., Quest, A.F.G., Kogan, M.J., Castro, P.F. and Lavandero, S. “Study protocol for the Maule Cohort (MAUCO) of chronic diseases, Chile 2014–2024”. BMC Public Health. 2016 Feb 4;16:122. PubMed Central
  • Guerrero, A.R., Oyarzun-Ampuero, F., Hassan, N., Corvalán, A.H., Quest, A.F.G., Kogan, M.J. “Gastric Cancer: Nanoparticles as Tools to Improve Treatment Efficacy”. Curr Pharm Des. 2016;22(39):5988-5997. PubMed Central

2015

  • Valenzuela, M., Canales, J., Corvalán, A.H., and Quest, A.F.G. “Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis”. World J Gastroenterol. 2015 Dec 7;21(45):12742-56. PubMed Central
  • Sanhueza, C., Wehinger, S., Castillo Bennett, J., Valenzuela, M., Owen, G.I., Quest, A.F.G. “The twisted survivin connection to angiogenesis”. Mol Cancer. 2015 Nov 19;14:198. PubMed Central
  • Oyarzun-Ampuero, F., Guerrero, A., Hassan-Lopez, N., Morales, J.O., Bollo, S., Corvalan, A.H., Quest, A.F.G., Kogan MJ. “Organic and Inorganic Nanoparticles for Prevention and Diagnosis of Gastric Cancer”. Curr Pharm Des. 2015;21(29):4145-54. PubMed Central
  • López-Crisosto, C., Bravo-Sagua, R., Rodriguez-Peña, M., Mera, C., Castro, P.F., Quest, A.F.G., Rothermel, B.A., Cifuentes, M., Lavandero, S. “ER-to-mitochondria miscommunication and metabolic diseases”. Biochim Biophys Acta. 2015 Oct;1852(10 Pt A):2096-105. PPubMed Central
  • Sung, H.H., Castro, I., González, S., Aguilera, S., Smorodinsky, N.I., Quest, A.F.G, Bahamondes, V., Alliende, C., Cortés, J., Molina, C., Urzúa, U., Barrera, M.J., Hermoso, M., Herrera, L., Leyton, C., González, M.J. “MUC1/SEC and MUC1/Y overexpression is associated with inflammation in Sjögren’s syndrome”. Oral Dis. 2015 Sep;21(6):730-738. PubMed Central
  • Silva, P., Soto, N., Díaz, J., Mendoza, P., Díaz, N., Quest, A.F.G., Torres, V.A. “Down-regulation of Rab5 decreases characteristics associated with maintenance of cell transformation”. Biochem Biophys Res Commun. 2015 Aug 21;464(2):642-646. PubMed Central
  • Barrera, M.J., Aguilera, S., Veerman, E., Quest, A.F.G., Díaz-Jiménez, D., Urzúa, U., Cortés, J., González, S., Castro, I., Molina, C., Bahamondes, V., Leyton, C., Hermoso, M.A., González, M.J. “Salivary mucins induce a Toll-like receptor 4-mediated pro-inflammatory response in human submandibular salivary cells: are mucins involved in Sjögren’s syndrome?”. Rheumatology (Oxford). 2015 Aug;54(8):1518-1527. PubMed Central
  • Diaz-Valdivia, N., Bravo, D., Huerta, H., Henriquez, S., Gabler, F., Vega, M., Romero, C., Calderon, C., Owen, G.I., Leyton, L. and Quest, A.F.G. “Enhanced caveolin-1 expression increases migration, anchorage-independent growth and invasion of endometrial adenocarcinoma cells”. BMC Cancer. 2015 Jun 10;15:463. PubMed Central – Open Access
  • Wehinger, S., Ortiz, R., Díaz, M.I., Aguirre, A., Valenzuela, M., Llanos, P., Mc Master, C., Leyton, L., Quest, A.F.G. “Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells”. Biochim Biophys Acta. 2015 May;1852(5):693-708. PubMed Central
  • Barrientos, G., Llanos, P., Hidalgo, J., Bolaños, P., Caputo, C., Riquelme, A., Sánchez, G., Quest, A.F.G., Hidalgo, C. “Cholesterol removal from adult skeletal muscle impairs excitation-contraction coupling and aging reduces caveolin-3 and alters the expression of other triadic proteins”. Front Physiol. 2015 Apr 10;6:105. PubMed Central
  • Herrera-Marschitz, M., Neira-Peña, T., Rojas-Mancilla, E., Morales, P., Bustamante, D., Leyton, L., Gebicke-Haerter, P. “Short- and long-term consequences of perinatal asphyxia: looking for neuroprotective strategies”. Adv Neurobiol. 2015;10:169-98. PubMed Central

2014

  • Díaz, J., Díaz, N., Leyton, L., Torres, V. and Quest, A.F.G. “Molecular insights to a novel Caveolin-1 Rab5-Rac1 signaling pathway important for metastatic cancer cell migration and invasion”. Cancer Cell & Microenviroment 2014; 1: e332
  • Ponce, D., Salech, F., SanMartin, C., Silva, M., Xiong, Ch., Roe, C., Henriquez, M., Quest, A.F.G. and Behrens, M.I. “Increased Susceptibility to Oxidative Death of Lymphocytes from Alzheimer Patients Correlates with Dementia Severity”. Curr Alzheimer Res. 2014;11(9):892-8. PubMed Central
  • Díaz, J., Mendoza, P., Silva, P., Quest, A.F.G.*, and Torres, V.A.* “A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion”. Commun Integr Biol. 2014 Oct; 7(5): e972850. *Corresponding authors (equal contribution). PubMed Central
  • Fernández, JG., Rodríguez, D., Valenzuela, M., Calderon, C., Urzúa, U., Munroe, D., Rosas, C., Lemus, C., Díaz, C., Wright, M., Leyton, L., Tapia, J., and Quest, A.F.G. “Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent transcription”. Mol Cancer 13: 209 (2014). PubMed Central
  • Díaz, J., Mendoza, P.,Ortiz, R., Díaz, N., Leyton, L., Stupack, D., Quest, A.F.G., Torres, V. “Rab5 is required in metastatic cancer cells for Caveolin-1-enhanced Rac1 activation, migration and invasion”. J Cell Sci. 127: 2401-2406 (2014). PubMed Central
  • Lobos-Gonzalez, L., Aguilar-Guzmán, L., Fernandez, J., Muñoz, N., Hossain, M., Bieneck, S., Silva, V., Burzio, V., Sviderskaya, E., Bennett, D., Leyton, L. and Quest, A.F.G. “Caveolin-1 is a risk factor for postsurgery metastasis in preclinical melanoma models”. Melanoma Res. 24:108-119 (2014). PubMed Central
  • Bravo-Sagua, R., Torrealba, N., Paredes, F., Morales P., Pennanen, C., López-Crisosto, C., Troncoso, R., Criollo, A., Chiong, M., Hill, J., Simmen, T., Quest, A.F.G., Lavandero, S. “Organelle communication: Signaling crossroads of homeostasis and disease”. Int J Biochem Cell Biol. 50:55-59 (2014). PubMed Central
  • Aguilar-Guzman, L., Lobos-Gonzalez, L., Rosas, C., Vallejos, G., , Falcon, C., Sosoniuk, E., Coddou, F., Leyton, L., Lemus, D., Quest, A.F.G.*, and Ferreira, A.* “Human Survivin and Trypanosoma cruzi Calreticulin Act in Synergy against a Murine Melanoma In Vivo”. PLoS One. 2014 Apr 22;9(4):e95457. *Corresponding authors (equal contribution). PubMed Central
  • Núñez-Wehinger, S., Ortiz, R., Díaz, N., Díaz, J., Lobos-González, L. and Quest, A.F.G. “Caveolin-1 in Cell Migration and Metastasis”. Curr Mol Med. 2014 Feb;14(2):255-274 (2014). PubMed Central
  • Díaz, J., Díaz, N., Leyton, L., Torres, V.A.*, and Quest, A.F.G.* “Molecular mechanisms implicated in Caveolin 1 dependent Rab5 activation, migration and invasion of metastatic cancer cells”. Cancer Cell & Microenvironment 2014; 1: e332. *Corresponding authors (equal contribution).
  • Ávalos, Y., Canales, J., Bravo-Sagua, R., Criollo, A., Lavandero, S. and Quest, A.F.G. “Tumor suppression and promotion by autophagy”. Biomed Res Int. 2014;2014:603980. PubMed Central
  • Leyton L, Torres VA, Quest A.F.G. “Editorial: Signaling in Cell Migration and Disease”. Curr. Mol. Med. 14: 197-198 (2014). PubMed Central
  • Cárdenas, A., Kong, M., Alvarez, A., Maldonado, H., Leyton, L. “Signaling pathways involved in neuron-astrocyte adhesion and migration”. Current Molecular Medicine 14(2):275-290 (2014). PubMed Central

Book Chapter

  • Leyton, L., and J. Hagood. “Thy-1 modulates neurological cell-cell and cell-matrix interactions through multiple molecular interactions” in “Cell Adhesion Molecules: Implications in Neurological Diseases”. Advances in Neurobiology. Editorial: Springer Science, New York, USA, Chapter 1, Páginas 3-20, 2014. PubMed Central

2013

  • Mendoza, P., Ortiz, R., Díaz, J., Quest,AFG., Leyton, L., Stupack, D., Torres, V. “Rab5 activation promotes focal adhesion disassembly, migration and invasiveness in tumor cells”. Journal of cell science. 126(12): 3835-3847 (2013). PubMed Central
  • Ormazabal, P., Romero, C., Quest, AFG., Vega, M. “Testosterone Modulates the Expression of Molecules Linked to Insulin Action and Glucose Uptake in Endometrial Cells”. Hormone and Metabolic Research. 45(09): 640-645 (2013). PubMed Central
  • Parra V., Moraga F., Kuzmicic J., López-Crisosto C., Troncoso R., Torrealba N., Criollo A., Díaz J., Rothermel B., Quest AFG., Lavandero S. “Calcium and mitochondrial metabolism in ceramide-induced cardiomyocyte death”. Biochim Biophys Acta. 1832:1334-1344 (2013). PubMed Central
  • Valenzuela M., Bravo D., Canales J., Sanhueza C., Díaz N., Almarza O., Toledo H., Quest AFG. “Helicobacter pylori-induced loss of survivin and gastric cell viability is attributable to secreted bacterial gamma-glutamyl transpeptidase activity”. J Infect Dis. 208: 1131-1141 (2013). PubMed Central
  • Lobos, L., Aguilar, L., Diaz, J., Diaz, N., Urra, H., Torres, V., Silva, V., Fitzpatrick, C., Lladser, A., Hoek, K., Leyton, L., Quest, AFG. “E‐cadherin determines Caveolin‐1 tumor suppression or metastasis enhancing function in melanoma cells”. Pigment cell & melanoma research. 26(4): 555-570. PubMed Central
  • Kong, M., Muñoz, N., Valdivia, A., Alvarez, A., Herrera-Molina, R., Cárdenas, A., Schneider, P., Burridge, K., Quest, A.F.G., and Leyton, L.“Thy-1-mediated Cell -Cell Contact Enhances Cell-Matrix Adhesion and Migration through the Engagement of αVβ3 Integrin and Syndecan-4”. BBA-Mol Cell Res. 1833:1409-1420 (2013). PubMed Central
  • Castro I., Sepúlveda D., Cortés J., Quest AFG., Barrera MJ., Bahamondes V., Aguilera S., Urzúa U., Alliende C., Molina C., González S., Hermoso MA., Leyton C., González MJ. “Oral dryness in Sjögren’s syndrome patients. Not just a question of water”. Autoimmun Rev. 12:567-574 (2013). PubMed Central
  • Barrera MJ., Bahamondes V., Sepúlveda D., Quest AFG., Castro I., Cortés J., Aguilera S., Urzúa U., Molina C., Pérez P., Ewert P., Alliende C., Hermoso MA., González S., Leyton C., González MJ. “Sjögren’s syndrome and the epithelial target: acomprehensive review”. J Autoimmun. 42:7-18 (2013). PubMed Central
  • Quest, A.F.G., Lobos-González, L., Nuñez, S., Sanhueza, C., Fernández, J.-G., Aguirre, A., Rodríguez, D., Leyton, L., Torres, V. “The caveolin-1 connection to cell death and survival”. Mol. Med. 13(2):266-81 (2013). PubMed Central
  • Smaili, SS., Quest,AF., Hetz, C., Lavandero, S. “Editorial: signaling in cell death, survival, proliferation and degeneration”. Current molecular medicine. 13(2): 239-240 (2013). PubMed Central
  • Aguirre, A., Shoji,KF., Sáez, JC., Henríquez, M., Quest, AFG. “FasL‐triggered death of Jurkat cells requires caspase 8‐induced, ATP‐dependent cross‐talk between fas and the purinergic receptor P2X(7)”. Journal of cellular physiology. 228(2): 485-493 (2013). PubMed Central
  • Ibarra C., Vicencio JM., Estrada M., Lin Y., Rocco P., Rebellato P., Muñoz JP., Garcia-Prieto J., Quest AFG., Chiong M., Davidson SM., Bulatovic I., Grinnemo KH., Larsson O., Szabadkai G., Uhlén P., Jaimovich E., Lavandero S. “Local control of nuclear calcium signaling in cardiac myocytes by perinuclear microdomains of sarcolemmal insulin-like growth factor 1 receptors”. Circ Res 112(2):236-245 (2013). PubMed Central
  • P Ormazabal, C Romero, F Gabler, AFG Quest, M Vega. “Decreased phosphorylation of Y¹⁴caveolin-1 in endometrial tissue of polycystic ovary syndrome patients may be related with an insulin resistant state in this tissue”. Hormone and metabolic research. 45(04):291-296 (2013). PubMed Central
  • Herrera-Molina, R., Valdivia, A., Kong, M., Alvarez, A., Cárdenas, A., Quest, AFG., Leyton, L. “Thy-1-interacting molecules and cellular signaling in both Cis and trans”. International Reviews of Cell and Molecular Biology. 305: 163-216 (2013). PubMed Central
  • Bravo R., Parra V., Gatica D., Rodríguez AE., Torrealba N., Paredes F., Wang ZV., Zorzano A., Hill JA., Jaimovich E., Quest AFG., Lavandero S. “Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration”. Int Rev Cell Moll Biol 301:215-290 (2013). PubMed Central
  • Fan Y., Abrahamsen G., Mills R., Calderón C., Tee J.Y., Leyton L., Murrell W., Cooper-White J., McGrath J.J., Mackay-Sim A. “Focal adhesion dynamics are altered in schizophrenia”. Biol Psychiatry. 74:418-426 (2013). PubMed Central

2012

  • Barrera MJ, Sánchez M, Aguilera S, Alliende C, Bahamondes V, Molina C, Quest AF, Urzúa U, Castro I, González S, Sung HH, Albornoz A, Hermoso M, Leyton C, González MJ. “Aberrant localization of fusion receptors involved in regulated exocytosis is salivary glands of Sjoegrens Syndrome patients is linked to ectopic mucin secretion”. Journal of Autoimmunity 39:83-92 (2012). PubMed Central
  • Urra, H., Torres, V.A., Ortiz, R., Lobos-Gonzalez, L., Díaz, M.I., Díaz, N., Härtel, S., Leyton, L.*, Quest, A.F.G.* “Caveolin-1-enhanced motility and focal adhesion turnover require tyrosine-14 but not accumulation to the rear in metastatic cancer cells”. PLoS One. 7(4):e33085.*Corresponding authors (equal contribution). PubMed Central
  • González, S., Aguilera, S., Urzúa, U., Quest,AFG., Molina, C., Alliende, C., Hermoso, M., González, M. Corrigendum to “Mechanotransduction and epigenetic control in autoimmune diseases”. J. Autoimmun. Rev. 11 (5) 375 (2012).
  • Herrera-Molina, R., Frischknecht, R., Maldonado, H., Seidenbecher, C.I., Gundelfinger, E.D., Hetz, C., Aylwin, M.L., Schneider, P., Quest, A.F.G., and Leyton, L. “Astrocytic αVβ3 Integrin Inhibits Neurite Outgrowth and Promotes Retraction of Neuronal Processes by Clustering Thy-1”. PLoS One. 7(3):e34295 (2012). PubMed Central
  • Castro, I., Aguilera, S., Brockhausen, I., Alliende, C., Quest, A.F.G.,Molina, C., Urzúa, U., Mandel, U., Bahamondes, V., Barrera, M.-J., Sánchez, M., González, S., Hermoso, M., Leyton, C., and González, M.-J. “Decreased salivary sulphotransferase activity correlated with inflammation and autoimmunity parameters in Sjoegrens Syndrome patients”. Rheumatology (Oxford). Mar;51(3):482-90 (2012). PubMed Central
  • Behrens, M.I., Silva, M., Salech, F., Ponce, D.P., Merino, D., Sinning, M., Xiong, C., Roe, C.M., Quest, A.F.G. “Inverse Susceptibility to Oxidative Death of Lymphocytes Obtained From Alzheimer’s Patients and Skin Cancer Survivors: Increased Apoptosis in Alzheimer’s and Reduced Necrosis in Cancer”. J Gerontol A Biol Sci Med Sci. glr258 (2012). PubMed Central
  • Bravo, R., Gutierrez, T., Paredes, F., Gatica, D., Rodriguez, A.E., Pedroso, Z., Chiong, M., Parra, V., Quest, A.F.G., Rothermel B.A., Lavandero, S. “Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics”. Int J Biochem Cell Biol:44, 16-20 (2012). PubMed Central
  • Perez-Donoso, J.M., Monras J.P., Bravo, D., Aguirre, A., Quest, A.F.G., Osorio-Roman, I.O., Aroca, R.F., Chasteen, T.G.,Vasquez, C.C. “Biomimetic, mild chemical synthesis of CdTe-GSH quantum dots with improved biocompatibility”. PLoS One. 7(1):e30741 (2012). PubMed Central
  • Copaja, M., Venegas, D., Aránguiz, P., Canales, J., Vivar, R., Avalos, Y., García, L., Chiong, M., Olmedo, I., Catalán, M., Leyton, L., Lavandero, S. and Díaz-Araya, G.“Simvastatin disrupts cytoskeleton and decreases cardiac fibroblast adhesion, migration and viability”. 294:42-49 (2012). PubMed Central
  • Diaz J, Aranda E, Henriquez S, Quezada M, Espinoza E, Bravo ML, Oliva B, Lange S, Villalon M, Jones M, Brosens JJ, Kato S, Cuello MA, Knutson TP, Lange CA, Leyton L., Owen GI. “Progesterone promotes focal adhesion formation and migration in breast cancer cells through induction of protease-activated receptor-1″J Endocrinol. 214(2):165-175 (2012). PubMed Central
  • A.F.G. Quest, V. Torres, D. Rodriguez, J. Gutierrez-Pajares, J.C. Tapia. Caveolin-1 in colon cancer: the flexible connection to Wnt signaling. Caveolins in Cancer Pathogenesis, Prevention and Therapy. 17-41 (2012)

2011

  • Armisén, R., Marcelain, K., Simon, F., Tapia, J.C., Toro, J., Quest, A.F.G., and Stutzin, A. “TRPM4 enhances cell proliferation through up-regulation of the β-catenin signaling pathway”. Cell Physiol 226: 103-109 (2011). PubMed Central
  • Bahamondes V., Albornoz A., Aguilera S., Alliende C., Molina C., Castro I., Urzúa U., Quest, A.F.G., Barrera M.J., González S., Sánchez M., Härtel S., Hermoso M., Leyton C., González M.J. “Changes in Rab3D expression and distribution in the acini of Sjögren’s syndrome patients are associated with loss of cell polarity and secretory dysfunction”. Arthritis Rheum. 2011 Oct; 63(10): 3126-35. doi: 10.1002/art.30500. PubMed Central
  • Behrens, M.I., Silva, M., Schmied, A., Salech, F., Manzur, H., Rebolledo, R., Bull, R., Torres, V., Henriquez, M., Quest, A.F.G. “Age-dependent increases in apoptosis/necrosis ratios in human lymphocytes exposed to oxidative stress”. J Gerontol A Biol Sci Med Sci 66: 732-740 (2011). PubMed Central
  • Bravo, D., Blondel, C.J., Hoare, A., Leyton, L.,Valvano, M.A., and Contreras, I. “Type IV(B) pili are required for invasion but not for adhesion of Salmonella enterica serovar Typhi into BHK epithelial cells in a cystic fibrosis transmembrane conductance regulator-independent manner”. Microb. Pathog. 51:373-377 (2011). PubMed Central
  • Copaja, M., Venegas, D., Aránguiz, P., Canales, J., Vivar, R., Catalán, M., Olmedo, I., Rodríguez, A.E., Chiong, M., Leyton, L., Lavandero, S. and Díaz-Araya, G. “Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts”. Toxicol. Appl. Pharmacol. 255:57-64(2011). PubMed Central
  • Ehrenfeld, P., Conejeros, I., Pavicic, M.F., Matus, C.E., Gonzalez, C.B., Quest, A.F.G., Bhoola, K.D., Poblete, M.T., Burgos, R.A., Figueroa, C.D. “Activation of kinin B1 receptor increases the release of metalloproteases-2 and -9 from both estrogen-sensitive and -insensitive breast cancer cells”. Cancer Letters 301: 106-118 (2011). PubMed Central
  • Gonzalez, S., Aguilera, S., Alliende, C., Urzua, U., Quest, A.F.G., Herrera, L., Molina, C., Hermoso, M., Ewert, P., Brito, M., Romo, R., Leyton, C., Perez, P., González M.J. “Alterations in Type-I hemidesmosome components suggestive of epigenetic control in the salivary glands of patients with Sjoegren’s syndrome”. Arthritis Rheum. 63:1106-1115 (2011). PubMed Central
  • Gonzalez, S., Aguilera, S., Urzua, U., Quest, A.F.G., Molina, C., Alliende, C., Hermoso, M., González M.J. “Mechanotransduction and epigenetic control in autoimmune diseases”. Autoimmune Rev, 10: 175-179(2011). PubMed Central
  • Henríquez, M, Herrera-Molina, R., Valdivia, A., Alvarez, A., Kong, M., Muñoz, N., Eisner, V., Jaimovich, E., Schneider, P., Quest, A.F.G.*, Leyton, L.* “ATP release due to Thy-1-integrin binding induces P2X7-mediated calcium entry required for focal adhesion formation” Cell Sci.124: 1581-1588(2011). *Corresponding authors (equal contribution). PubMed Central
  • Henríquez, S., Calderon, C., Quezada, M., Oliva , B., Bravo, M.L., Aranda, E., Kato, S., Cuello, M.A., Gutiérrez, J., Quest , A.F.G., and Owen, G.I. “Progesterone utilizes distinct membrane pools of Tissue Factor to increase coagulation and invasion and these effects are inhibited by TFPI” Cell Physiol. 226: 3278-3285(2011). PubMed Central
  • Herrera-Marschitz M, Morales P, Leyton L, Bustamante D, Klawitter V, Espina Marchant P, Allende C, Lisboa F, Cunich G, Jara-Cavieres A, Neira T, Gutierrez-Hernandez M.A., Gonzalez-Lira V, Simola N, Schmitt A, Morelli M, Tasker A, Gebicke-Haerter P.J. “Perinatal asphyxia: current status and approaches towards neuroprotective strategies, with focus on sentinel proteins”. Neurotox Res. 19(4):603-627 (2011). PubMed Central
  • Lladser, A.,*Sanhueza, C., Kiessling, R., Quest, A.F.G.* “Is survivin the potential archilles’ heel of cancer?” (invited review) Advances in Cancer Research 111: 1-37(2011). *Corresponding authors (equal contribution). PubMed Central
  • Lladser, A., Mougiakakos, D., Tufvesson, H., ,Ligtenberg, M.A., Quest, A.F.G., Kiessling R., Ljungberg, K. “DAI (DLM-1/ZBP1) as a DNA genetic adjuvant for DNA vaccines that promotes effective antitumor CTL immunity”. Mol Ther. 19: 594-601 (2011). PubMed Central
  • Yefi, R.,, Ponce, D.P., Niechi, I., Silva, E., Cabello, P., Rodríguez, D.A., Marcelain, K., Armisen, R., Quest, A.F.G.*, Tapia, J.* “Protein kinase CK2a promotes cancer cell viability via upregulation of cyclooxygenase-2 expression and enhanced PGE2 production¨ Cell. Biochem 226: 1953-1959 (2011). *Corresponding authors (equal contribution). PubMed Central

2010

  • Ewert P., Aguilera S., Alliende C., Kwon Y.J., Albornoz A., Molina C., Urzúa U., Quest A.F., Olea N., Pérez P., Castro I., Barrera M.J., Romo R., Hermoso M., Leyton C., González M.J. “Disruption of tight junction function in salivary glands from Sjoegren’s syndrome patients is linked to pro-inflammatory cytokine exposure”Arthritis Rheum 62: 1280-1289 (2010). PubMed Central
  • Lladser, A., Ljungberg, K., Tufvesson, H., Tazzari, M., Roos, A.-K., Quest, A.F.G., Kiessling, R. “Intradermal DNA electroporation induces survivin-specific CTLs, suppresses angiogenesis and confers protection against mouse melanoma”. Cancer Immunol. Immunother. 59:81-92 (2010). PubMed Central
  • Valenzuela, M., Perez-Perez,, Corvalán, A.H., Carrasco, G., Urra, H., Bravo, D., Toledo, H., and Quest A.F.G. “Helicobacter Pylori-induced loss of the inhibitor of apoptosis protein survivin is linked to gastritis and death of human gastric cells” J. Inf. Disease 202: 1021-1030 (2010). PubMed Central
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